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COMPLEMENT FACTOR I
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DeCS
Descriptor
English
:
Complement Factor I
Descriptor
Spanish
:
Factor I de Complemento
Descriptor
Portuguese
:
Fator I do Complemento
Tree Number:
D08.811.277.656.300.760.210
D08.811.277.656.959.350.210
D12.776.124.486.274.920.325.210
Definition
English
:
A
plasma
serine
proteinase that cleaves the alpha-chains of C3b and C4b in the presence of the cofactors
COMPLEMENT FACTOR H
and C4-binding protein, respectively. It is a 66-kDa glycoprotein that converts C3b to inactivated C3b (iC3b) followed by the release of two fragments, C3c (150-kDa) and C3dg (41-kDa). It was formerly called KAF, C3bINF, or enzyme 3b inactivator.
Indexing Annotation
English
:
do not confuse with FACTOR I see
FIBRINOGEN
Pharmacological Action:
Complement Inactivating Agents
History Note
English
:
93; was FACTOR I, C 3B INACTIVATOR (NM) 1983-92
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
30774
Unique Identifier:
D017244
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
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